In announcing the selection, Debrabati Maiti, Editor-in-Chief of SYNLETT, stated: “This manuscript was selected as the “Best Paper” for its elegant integration of modern photoredox catalysis with nickel-mediated cross-coupling to address a long-standing challenge in carbohydrate chemistry. The award is presented to Kazuteru Usui and Go Hirai for the development of a highly α-selective and broadly applicable synthesis of C-aryl glycosides from readily available glycosyl bromides and aryl bromides. The work is distinguished by its conceptual clarity, mild reaction conditions, and strong emphasis on stereochemical control without reliance on pre-functionalized organometallic reagents.The synthetic strategy combines photoredox activation, silyl-radical-mediated halogen atom transfer, and nickel-catalyzed reductive cross-electrophile coupling into a streamlined and operationally simple protocol. The use of conformationally restricted glycosyl bromides enables exceptional α-stereoselectivity across a wide substrate scope, including glucosyl-, galactosyl-, and mannosyl donors, as well as heteroaryl and amino-acid-derived aryl bromides. This study provides a robust and mechanistically insightful platform for the synthesis of C-aryl glycosides, bridging fundamental radical chemistry with practical synthetic design and offering valuable tools for chemical biology and medicinal chemistry applications.”